Bayesian Modeling in Bioinformatics (Chapman & Hall/CRC by Dipak K. Dey,Samiran Ghosh,Bani K. Mallick

By Dipak K. Dey,Samiran Ghosh,Bani K. Mallick

Bayesian Modeling in Bioinformatics discusses the improvement and alertness of Bayesian statistical equipment for the research of high-throughput bioinformatics information bobbing up from difficulties in molecular and structural biology and disease-related scientific examine, similar to melanoma. It offers a huge review of statistical inference, clustering, and category difficulties in major high-throughput systems: microarray gene expression and phylogenic analysis.

The ebook explores Bayesian suggestions and versions for detecting differentially expressed genes, classifying differential gene expression, and selecting biomarkers. It develops novel Bayesian nonparametric techniques for bioinformatics difficulties, size errors and survival versions for cDNA microarrays, a Bayesian hidden Markov modeling procedure for CGH array info, Bayesian methods for phylogenic research, sparsity priors for protein-protein interplay predictions, and Bayesian networks for gene expression info. The textual content additionally describes functions of mode-oriented stochastic seek algorithms, in vitro to in vivo issue profiling, proportional dangers regression utilizing Bayesian kernel machines, and QTL mapping.

Focusing on layout, statistical inference, and knowledge research from a Bayesian point of view, this quantity explores statistical demanding situations in bioinformatics info research and modeling and provides suggestions to those difficulties. It encourages readers to attract at the evolving applied sciences and advertise statistical improvement during this region of bioinformatics.

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